Abstract #2297

Age-associated changes in skeletal muscle morphology assessed by intramuscular adipose and connective tissue

Bharath Ambale Venkatesh¹, Yoko Kato², Jaclyn Sesso², Jason Ortman², John Pitts³, Michio Ozaki², Yoshimori Kassai⁴, and Joao AC Lima²

¹Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Johns Hopkins University, Baltimore, MD, United States, ³Toshiba Medical Research Institute USA Inc, Mayfield Village, OH, United States, ⁴Toshiba Medical Systems Corporation, Tochigi, Japan

In human skeletal muscles, the aging process causes a decrease of contractile function likely associated with an increase in intramuscular adipose and connective tissues. The accumulation of non-contractile tissues and loss of muscle tissue may contribute to sarcopenia and frailty observed at older age but their quantification is challenging1. The purpose of this study was to establish MR imaging-based methods to quantify the relative amounts of fat and connective tissue in healthy human subjects, and investigate their association with age.

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