Abstract #2292

Relative perfusion mapping using BOLD imaging with induced hypoxia

Chau Vu¹, Julie Coloigner², Soyoung Choi^3,4, and John Wood^1,4

¹Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ²Division of Radiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States, ³Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, United States, ⁴Division of Cardiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States

DSC MRI is a popular perfusion technique that requires the use of an invasive exogenous contrast. This study proposes an alternative technique which uses BOLD imaging and 100% nitrogen inhalation to map relative perfusion values (rCBV, rCBF and rMTT) without the use of contrast. We evaluated its performance on a cohort of healthy controls and sickle cell disease patients with a large range of global cerebral blood flow.

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