The present study is designed to show physiological markers of tinnitus in rodents. The tinnitus is an auditory phantom sensation experienced in absence of an external stimulus. The prevalence of tinnitus shows a worrying growth curve with the development of new lifestyles (exposure to noise, urbanization, …). One promising tool is used, called Manganese Enhanced MRI (MEMRI). The use of manganese chloride as an MRI contrast agent enables to follow brain neuronal activity. T1-weighted MRI images are collected in order to investigate the specific areas activated in presence of tinnitus or not. Two analysis methods are used: Statistical analysis by Signal to Noise Ratio (SNR) and T2 rate cartography. Results enable to shown a complementary between the two analysis methods and allows us to discriminate between healthy and tinnitus rats.
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