Abstract #2175

Pushing the Limits of ASL Imaging for the Lifespan Human Connectome Projects

Xiufeng Li¹, Dingxin Wang¹, Steen Moeller¹, Danny JJ Wang², Michael Chappell³, Essa Yacoub¹, and Kamil Ugurbil¹

¹Center for Magnetic Resonance Research, School of Medicine, University of Minnesota, Minneapolis, MN, United States, ²Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, United States, ³Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, United Kingdom

Arterial spin labeling (ASL) imaging is included in the Lifespan Human Connectome Projects (HCPs) in order to investigate the evolution of cerebral blood flow (CBF) in children and elderly populations. To push the limits of ASL imaging for the Lifespan HCPs, we optimized and evaluated high-resolution 2D slice accelerated protocols for multi-delay PCASL imaging. The results suggest that high quality arterial transit time (ATT) and CBF maps with a 2.5 mm resolution can be reliably achieved in about 5.5 minutes.

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