Abstract #2174

Investigating Cerebrovascular Reactivity Using Pseudo-continuous ASL and Turbo QUASAR ASL at Varying Blood Flow Conditions

Moss Y Zhao¹, Lena Vaclavu², Esben T Petersen³, Henk-Jan Mutsaerts^2,4,5, Bart J Biemond⁶, Ed T van Bavel⁷, Charles B Majoie², Aart J Nederveen², and Michael A Chappell¹

¹Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ²Department of Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, Netherlands, ³Danish Research Centre for Magnetic Resonance, Copenhagen, Denmark, ⁴Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Rochester Institute of Technology, Rochester, NY, United States, ⁶Department of Haematology, Academic Medical Center, Amsterdam, Netherlands, ⁷Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands

CVR has become an important biomarker to assess cerebrovascular health, and ASL is a non-invasive technique to quantify CVR. This work compared the CVR measurement from PCASL and Turbo QUASAR ASL at varying blood flow conditions induced by acetazolamide. Results showed that both ASL techniques were sensitive to CVR and that significant changes of ATT were detected by Turbo QUASAR ASL. The differences in CVR (higher in PCASL) may be due to the different sensitivity to ATT of the two ASL methods.

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