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Abstract #2065

Relationships among cerebrovascular reactivity, grey matter volume and markers of successful aging

Brittany Intzandt1, Dalia Sabra2, Laurence Desjardins-Crepeau3,4, Said Mekary5, Louis Bherer3,4,6, Richard D Hoge7,8, Christopher J Steele9,10, and Claudine J Gauthier11,12

1Concordia University, Montreal, QC, Canada, 2Biomedical Sciences, Universite de Montreal, Montreal, QC, Canada, 3Montreal Heart Institute, Montreal, QC, Canada, 4Laboratoire d'Étude de la Santé Cognitive des Ainés, Centre de recherche de l'Institut universitaire de gériatrie de Montréal, Montreal, QC, Canada, 5Kinesiology, Acadia University, Wolfville, NS, Canada, 6Medicine, Universite de Montreal, Montreal, QC, Canada, 7Montreal Neurological Institute, Montreal, QC, Canada, 8Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, 9Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 10Cerebral Imaging Center, Douglas Mental Health University Institute- McGill University, Montreal, QC, Canada, 11Physics, Concordia University, Montreal, QC, Canada, 12PERFORM Centre, Montreal, QC, Canada

Aging causes decline in brain health, which has a complex relationship with fitness and cognition. Here, we aimed to disentangle the interactions between these outcomes in healthy older adults. MRI was used to acquire anatomical and cerebrovascular reactivity (CVR) in all participants. VO2max and cognitive outcomes were also tested. Results revealed that increased CVR was associated with decreased fitness and cognitive performance, whereas increased grey matter volume was associated with increased fitness. It is apparent that the relationship between brain health and fitness and cognitive outcomes is intricate and other parameters, such as cerebral blood flow, are necessary to gain further understanding.

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