Abstract #1960

Progressive white matter changes in the pilocarpine-induced temporal lobe epilepsy with focal seizure rat model: A diffusion tensor imaging study

Yao-Chia Shih^1,2, Chih-Hsien Tseng^1,2, Fang-Chia Chang³, Horng-Huei Liou^4,5, and Wen-Yih Issac Tseng^2,5,6

¹Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, ²Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ³Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan, ⁴Department of Neurology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, ⁵Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan, ⁶Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

A more suitable pilocarpine rat model with microinjection into the left central nucleus of the amygdala and in-vivo diffusion tensor imaging acquisitions were used to investigate progressive changes in the white matter fibers at three different time points during epileptogenesis in temporal lobe epilepsy (TLE) with focal seizure. We found transient fractional anisotropy (FA) changes in the left fimbria of the hippocampus after status epilepticus and subsequent FA changes in the left cingulum after the presence of spontaneous recurrent seizure. The results demonstrate potential imaging markers for monitoring the progression and development of TLE with focal seizure.

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