Abstract #1924

Determination of White Matter Tracts Implicated in Postural Gait Instability Disorder through Tract-Based Automated Analysis

Leon Qi Rong Ooi¹, Chu Ning Ann¹, Yun-Chin Hsu², Chen-Hsiang Weng², Ming-Ching Wen¹, HuiHua Li³, Helmut Rumpel^4,5, Eng King Tan^1,5,6, Wen-Yih Isaac Teng^2,7, and Ling Ling Chan^4,5

¹Department of Research, National Neuroscience Institute, Singapore, Singapore, ²Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ³Health Services Research Unit, Singapore General Hospital, Singapore, Singapore, ⁴Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, ⁵Duke-NUS Medical School, Singapore, Singapore, ⁶Department of Neurology, Singapore General Hospital, Singapore, Singapore, ⁷Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

Tract-Based Automated Analysis (TBAA) in Diffusion Tensor Imaging allows for the study of microstructural properties along the tracts in white matter. Diffusivity measures extracted from TBAA for various tracts of the brain were correlated to Tinetti Balance Scale scores in Parkinson's Disease and Postural Gait Instability Disorder patients, allowing identification of tracts of interest in the pathological study of the diseases.

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