Abstract #1923

Cerebral blood flow in a resuscitated septic shock population: an ASL study

Marie Anne Richard^1,2, Marie-Hélène Masse^1,2, Frédérick D'Aragon^1,2, Charles St-Arnaud¹, Michael Mayette¹, Steven Palanchuck¹, Etienne Croteau^1,2, Neil Adhikari³, William Fraser^1,2, André Carpentier^1,2, David Gauthier¹, Luc Lanthier¹, Matthieu Touchette¹, Albert Lamontagne¹, Jean Chénard¹, Sangeeta Mehta⁴, Yanick Sansoucy¹, François Lamontagne^1,2, and Martin Lepage^1,2

¹Université de Sherbrooke, Sherbrooke, QC, Canada, ²Centre de recherche du CHUS, Sherbrooke, QC, Canada, ³Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Mount Sinai Hospital, Toronto, ON, Canada

Reduced cerebral blood flow (CBF) is often blamed for sepsis-associated encephalopathy. The present study compares the CBF and blood oxygen consumption (CMRO₂) of healthy subjects and resuscitated septic patients under vasopressor (norepinephrine) treatment. Methods used are pseudo-continuous arterial spin labeling (PCASL) and T2-relaxation-under-spin-tagging (TRUST). We find that septic patients have elevated global and regional CBF, whereas CMRO₂ seems reduced. Further studies are needed to elucidate the underlying mechanisms of this apparent uncoupling.

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