We explored the link between neuroinflammation and related changes in tissue susceptibility by using quantitative susceptibility mapping (QSM) in a clinically well characterized cohort including inflammatory NP-SLE, ischemic NP-SLE and SLE patients. No significant differences were found after stratifying all patients for antibodies, SLE activity, cumulative SLE damage or complement components in subcortical structures. Subanalysis of inflammatory NP-SLE patients showed a residual correlation between QSM values in the globus palidus and low C1q levels, which need further investigation. Current work is underway to analyse QSM in a bigger sample size to further investigate its potential in identifying NP-SLE patients.
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