Electroconvulsive therapy (ECT) is an effective choice for patients with untreatable depression. Although it is very effective, the mechanisms through which ECT works are poorly understood. We have previously collected PET/MRI data in patients receiving ECT which suggest that this treatment strongly affects the hippocampus. Herein, we supplement these preexisting data with arterial spin labeling data showing significantly reduced blood flow to the hippocampus following ECT in three responders.
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