A PCA analysis of fractional anistropy (FA) was conducted from a sample of schizophrenia patients (n=42) and healthy controls (n=40) resulted in three major components: “corpus callosum”, “internal capsule/temporal/brainstem”, and “corona radiata”. Average component scores did not differ as a function of group, but a correlation of PSYRATS scores and principal components revealed the frequency, amount of distress associated with voices, and disruption associated with voices correlated significantly with the corpus callosum component. Our findings suggest that reduced interhemispheric connectivity of the prefrontal cortex is related to hallucination severity in schizophrenia, perhaps mediated through top-down processes such as source monitoring.
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