Abstract #1352

Characterizing altered glucose and glutamine metabolism in castration-resistant prostate cancer using high-resolution NMR

Jinny Sun¹, Renuka Sriram², Robert Bok², Romelyn Delos Santos², Mark Van Criekinge², Daniel Vigneron², and John Kurhanewicz²

¹UC Berkeley – UCSF Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA, United States, ²Department of Radiology and Biomedical Imaging, University of California, San Fracisco, San Francisco, CA, United States

This study demonstrates significant increases in flux through aerobic glycolysis, oxidative phosphorylation, and glutaminolysis with development of therapeutic resistance to androgen deprivation therapy using patient-derived cell lines and a transgenic murine model. Based on these metabolic differences between androgen-sensitive and insensitive prostate cancer, a combination of hyperpolarized [1-¹³C]pyruvate, [2-¹³C]pyruvate and [5-¹³C]glutamine can be used to noninvasively predict therapeutic resistance in future patient studies using HP ¹³C MRI.

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