The purpose of the study is to investigate neurochemical changes in a mouse model using proton magnetic resonance spectroscopy. Animals received 1% of ethanol drinking water solution or 100μg/mL of corticosterone dissolved in 1% of ethanol drinking water for 4 weeks. MRS spectra were acquired at the end of the experiment. Mice that ingested corticosterone show elevated glutamate, glycerophosphocholine and taurine levels in the hippocampus compared with those shown by the control group. Increased corticosterone levels are considered a sign of stress or metabolic disturbance. Therefore we suggest that chronic corticosterone exposure can affect the hypothalamic-pituitary-adrenal dysregulation and neurochemical alteration.
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