Abstract #1346

Tracking changes in glutamate using dynamic MRS in response to an acutely painful stimulus.

Jessica Archibald^1,2, Erin L Macmillan^3,4,5, Carina Graf^2,6, Cornelia Laule^2,6,7, and John L.K Kramer^1,2

¹Kinesiology, University of British Colombia, Vancouver, BC, Canada, ²International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, ³Radiology, University of British Colombia, Vancouver, BC, Canada, ⁴ImageTech Lab, SFU, Simon Fraser University, Vancouver, BC, Canada, ⁵Philips Healthcare Canada, Philips, Vancouver, BC, Canada, ⁶Physics and Astronomy, University of British Colombia, Vancouver, BC, Canada, ⁷Pathology and Laboratory Medicine, University of British Colombia, Vancouver, BC, Canada

Current treatment and diagnosis of pain conditions are dependent on self-reported measures. The objective of this study was to establish the feasibility of determining changes in excitatory neurotransmitter concentrations (glutamate) in the anterior cingulate cortex (ACC) as an objective measure of pain using dynamic single voxel magnetic resonance spectroscopy (MRS). Glutamate levels can accurately be detected with this paradigm, although a general trend in relation to pain was not observed across subjects. This is the first study to report dynamic levels of glutamate in the ACC in relation to pain in healthy individuals using optimized MRS acquisition and processing methods.

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