Abstract #1293

Accuracy and Reproducibility of NAD+, NADH and Redox Ratio Measurement in Human Brain by LCModel

Lijing Xin¹, Ozlem Ipek¹, Bernard Cuenoud², Maurice Beaumont², Maya Shevlyakova², and Rolf Gruetter^3,4

¹Centre d'Imagerie BioMédicale (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Nestec Ltd, Avenue Nestlé 55, Vevey, Switzerland, ³Departments of Radiology, University of Lausanne, Lausanne, Switzerland, ⁴Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

The aims of this study were to test the feasibility of NAD⁺, NADH and redox ratio([NAD⁺/NADH]) measurement in vivo in the human brain at 7T using LCModel and to further evaluate the measurement accuracy and reproducibility. High ³¹P spectral quality was achieved and LCModel provides excellent fitting quality. Monte-Carlo simulations and test-retest experiments demonstrated good measurement accuracy and reproducibility with sufficient SNR achieved. The values are in agreement with those previously published. Therefore, LCModel can be used as an alternative tool to achieve automated and objective measurement of NAD⁺, NADH and redox ratio in human brain in vivo.

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