Multi-TR, multi-TE 1H MRS estimates T1 and T2 of fat and water and liver proton density fat fraction in a single breath-hold. This approach uses a steady state solution, which assumes a perfect 90° pulse is generated which is not guaranteed in vivo, possibly introducing T1 errors. We introduce a flip angle corrected multi-TR, multi-TE 1H MRS sequence based on a non-steady state approach and demonstrate, in phantoms, that while the multi-TR, multi-TE MRS sequence estimates T1 dependent on the flip angle, the flip angle corrected multi-TR, multi-TE MRS sequence estimates T1 independent of flip angle.
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