Whole-Body Diffusion-Weighted-MRI is emerging as an imaging response biomarker in metastatic bone disease. Tumour heterogeneity resulting in differential response to therapy is a well-recognized phenomenon. We propose that calculating radiomic features from the apparent diffusion coefficients within individual lesions can identify differential response patterns in whole-body bone disease. Robust statistical assessment of radiomic features based on repeatability assessment aids identification of significant changes.
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