Abstract #1081

Altered Right-Heart 3D Blood Flow and Kinetic Energy in Chronic Obstructive Pulmonary Disease. The MESA COPD Study

Haben Berhane¹, Ozair Rahman², Pallavi Balte³, Kenichiro Suwa², Stephen Dashnaw³, David A. Bluemke⁴, Martin R. Prince^5,6, Bharath Venkatesh⁷, Joao Lima⁷, James Carr², Antoinette S. Gomes⁸, Karol Watson⁸, Cynthia Rigsby¹, R. Graham Barr³, and Michael Markl²

¹Department of Medical Imaging, Lurie Children's Hospital, Chicago, IL, United States, ²Department of Radiology, Northwestern University, Chicago, IL, United States, ³Department of Medicine and Epidemiology, Columbia University, New York, NY, United States, ⁴Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ⁵Department of Radiology, Weill Cornell Medical College, New York, NY, United States, ⁶Department of Radiology, Columbia College of Physicians and Surgeons, New York, NY, United States, ⁷Division of Cardiology, John Hopkins University, Baltimore, MD, United States, ⁸Department of Medicine, UCLA, Los Angeles, CA, United States

Chronic Obstructive Pulmonary Disease (COPD) affects over 65 million people worldwide and is the third leading cause of death in the US. The aim of this feasibility study was to employ 4D-flow MRI for the comprehensive assessment of the effects of COPD on right-sided hemodynamics. Measures of blood kinetic energy (KE) were used to quantify hemodynamic changes in COPD patients compared to controls. Findings showed a significant increase in KE in the right atrium across increasing categories of COPD severity. Right-sided 4D flow MRI maybe a promising tool for the detection of hemodynamic disruptions in COPD and other vasoconstrictive diseases.

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