The chemical shift of 129Xe dissolved in red blood cells was measured at increasing transit times from the gas exchange region of the lungs of healthy rats and rats exposed to hyperoxia/hypoxia, a model of bronchopulmonary dysplasia. The results show that the chemical shift decreased with increasing transit times. Furthermore, the chemical shift was different between the healthy and exposed cohorts. A possible mechanism for this phenomenon based on changes in bulk magnetic susceptibility distal to the lungs is proposed.
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