Abstract #0971

In Vivo Hyperpolarized 129Xe Diffusion Morphometry of the Mouse Lung

Matthew S. Freeman¹, Teckla G. Akinyi^1,2, Jinbang Guo¹, Cory B. Davis^1,3, James D. Quirk⁴, Brian M. Varisco⁵, Jason C. Woods^1,4, and Zackary I. Cleveland^1,2

¹Center for Pulmonary Imaging Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, ²Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, ³Department of Physics, West Texas A&M University, Canyon, TX, United States, ⁴Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States, ⁵Division of Critical Care Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States

Hyperpolarized ¹²⁹Xe diffusion morphometry allows the microstructural dimensions of the lungs to be measured noninvasively, providing a means to quantify normal alveolar growth and disease progression in disorders such as emphysema. In the preclinical setting, ¹²⁹Xe diffusion morphometry holds the potential to provide insights into fundamental pulmonary biology and to assess the efficacy of potential therapies. However, to have the greatest impact on pulmonary biomedicine, this approach must be applied reliably to mouse models, where tools to investigate disease mechanisms are most highly developed. Here, we demonstrate the feasibility of high-resolution, ¹²⁹Xe diffusion morphometry in living mice.

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