Abstract #0507

The Evolution of White Matter Microstructural Changes after Mild Traumatic Brain Injury: A Longitudinal DTI and NODDI Study

Eva M Palacios¹, Julia P Owen², Esther L Yuh^1,3, Mary Vassar^3,4, Geoffrey T Manley^3,4, and Pratik Mukherjee^1,3,5

¹Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Department of Radiology, University of Washington, Seattle, WA, United States, ³Brain and Spinal Cord Injury Center, San Francisco General Hospital and Trauma Center, San Francisco, CA, United States, ⁴Department of Neurological Surgery and Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, United States, ⁵Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States

Problem: Mild traumatic brain injury (mTBI) can result in long-term sequelae. Lack of sensitive biomarkers makes diagnosis challenging. Methods: Cross-sectional and longitudinal study of 40 mTBI patients at 2 weeks and 6 months after injury. Diffusion tensor imaging and multishell neurite orientation dispersion and density imaging (NODDI) parameters were assessed. Results: Cross-sectional analysis between patients at 2-weeks and controls revealed a decrease of fractional anisotropy and increase of mean diffusivity in the patient group together with elevated free water values. Longitudinally, after mTBI, a decline in neurite density was observed. Conclusions: NODDI measurements are sensitive imaging biomarkers for the subtle underlying white matter pathology after mTBI.

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