Traditional streamline tractography does not capture the changes in fiber twisting resulting from traumatic brain injury. We used ribbon tractography to quantify the acute directional changes in white matter tracts in patients with traumatic brain injury. We identified significant changes in the corpus callosum of these patients both as compared to healthy controls and between the acute and follow-up scans of a subset of patients. These findings reveal alterations in the architecture of the corpus callosum within and beyond the area of injury and offer a potential marker for structural changes that are not detected by standard techniques.
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