Abstract #0236

Deletion of CRTC1 is associated with strong neuroenergetic dysfunctions in a mouse model of mood disorders.

Antoine Cherix¹, Guillaume Donati¹, Blanca Lizarbe¹, Hongxia Lei², Carole Poitry-Yamate², Jean-René Cardinaux³, and Rolf Gruetter^1,4,5

¹Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Animal Imaging and Technology Core (AIT), Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne., Lausanne, Switzerland, ³Center for Psychiatric Neuroscience (CNP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, ⁴Department of Radiology, University of Geneva, Geneva, Switzerland, ⁵Department of Radiology, University of Lausanne, Lausanne, Switzerland

This project pursues a previous study presented at ISMRM¹ which established an age- and brain region dependent neurochemical metabolic profile in a Crtc1^-/- based mouse model of mood disorders. Here, we show that a decline in cerrebral lactate levels is a consistent and reliable endophenotype² of Crtc1 deletion, and an indicator of neuroenergetic dysfunction in the dorsal hippocampus. The decline in brain lactate levels appears to arise from a measured reduction of glucose entering the brain.

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