Abstract #5656

Simultaneous Quantification of Body and Liver Fat using MRI and 1H MRS: Their Associations with Adipokines in Patients with Antipsychotics

Jong-Hee Hwang¹, Jung-Hyun Kim², Pil-Whan Park³, JÃ¼rgen Machann⁴, Michael Roden¹, Sheen-Woo Lee⁵, and Jong-Hoon Kim⁶

¹Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research, Heinrich Heine University, DÃ¼sseldorf, Germany, ²Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea, Republic of, ³Department of Laboratory Medicine, Gachon University, Incheon, Korea, Republic of, ⁴Department of Diagnostic and Interventional Radiology, University Hospital TÃ¼bingen, TÃ¼bingen, Germany, ⁵Department of Radiology, Gachon University, Incheon, Korea, Republic of, ⁶Neuroscience Research Institute, Gachon University, Incheon, Korea, Republic of

To date, quantitative analyses of body fat content along with key adipokines have not been reported for patients treated with antipsychotics. Thus, in the groups of schizophrenia patients with antipsychotic treatment and age- and body mass index (BMI) matched healthy controls, we report abdominal and liver fat content by MRI and ¹H MRS, plasma levels of leptin and adiponectin, and their associations. As a result, liver fat content was inversely correlated with adiponectin levels in age- and BMI- matched controls (r=-0.873, p=0.0004), but not in the patients. In both groups, visceral fat was inversely correlated with adiponectin, while subcutaneous fat was positively correlated with leptin levels.

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