Abstract #5349

Dexmedetomidine-induced CBF changes measured with Arterial Spin Labeling

Marta Vidorreta^1,2, Sihua Xu³, Fan N Yang³, Andrew McKinstry-Wu⁴, Alexander Proekt⁴, Brenna Shortal⁴, Hengyi Rao³, Max B Kelz⁴, and John A Detre^1,2

¹Neurology, University of Pennsylvania, Philadelphia, PA, United States, ²Radiology, University of Pennsylvania, Philadelphia, PA, United States, ³Neurology, University of Pennsylvania, PA, United States, ⁴Anesthesiology, University of Pennsylvania, PA, United States

Dexmedetomidine infusion was used to induce pharmacological unconsciousness akin to natural non-REM sleep, and brain resting-state activity changes were monitored using Arterial Spin Labeling and EEG recordings.

Our results confirm that functional changes associated with non-REM sleep in both centrencephalic and cortical structures can be monitored with ASL, revealing that selective regional CBF decreases are associated with the loss of consciousness, most significantly in the reticular activating system. The thalamic/cortical GM CBF ratio was also found to be a reliable marker of conscious state.

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