Functional magnetic resonance imaging (fMRI) measures the hemodynamic response to neural activation. Brief periods (2 s) of multisensory neural stimulation evoke the hemodynamic response function (HRF) across the majority of cerebral cortex. High (2 mm) spatial resolution enables the characterization of the HRF restricted to the gray matter, avoiding partial volume effects into nearby white matter and vascular tissue. HRF amplitude and timing measurements from eight healthy subjects showed temporal stability and stereotypical spatial amplitude patterns, suggesting that this method could be adapted to diagnose pathologies associated with abnormal neurovascular coupling.
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