We designed a novel PET insert based on monolithic LYSO crystals. From our first evaluation, we can conclude that sub-millimeter detector spatial resolution, combined with accurate photon DOI determination, make it possible to acquire high resolution reconstructed images. This enables us now to combine simultaneously high resolution and sensitivity PET with high field preclinical MRI to extract simultaneously complex data from anatomical to molecular information and to dynamically follow non-invasively animal models of different pathologies with no compromise in performance of each imaging modality.
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