Abstract #4626

FEAST based Arterial Transit Time Measurement using Pseudo Continuous Arterial Spin Labeling in Patients with Sickle Cell Disease

Yihao Xia¹, Yaqiong Chai^2,3, Adam M Bush², Natasha Lepore³, Thomas Coates⁴, and John Wood^3,5

¹Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States, ²Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ³Radiology, Children's Hospital of Los Angeles, Los Angels, CA, United States, ⁴Section of Hematology, Children's Hospital of Los Angeles, Los Angels, CA, United States, ⁵Division of Cardiology, Children's Hospital of Los Angeles, Los Angels, CA, United States

Sickle cell disease (SCD) is a genetic blood disorder with a high prevalence of cerebral vasculopathy and stroke. Arterial Transit Time (ATT) refers to the time it takes blood to flow from the labeling plane, to the vascular imaging compartment and reflects cerebrovascular impairment in SCD. We used pseudo continuous arterial spin labeling to measure ATT with flow encoding arterial spin tagging technique in patients with SCD and ethnicity matched, healthy controls. Our findings demonstrated sensitivity of ATT to vasculopathy.

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