Abstract #4625

Assessment of cerebral perfusion changes in asymptomatic internal carotid artery stenosis using multi-parametric arterial spin-labeling MRI

Ya-Fang Chen¹, Sung-Chun Tang², Yen-Shu Kuo^3,4, and Wen-Chau Wu^5,6

¹Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, ²Neurology, National Taiwan University Hospital, Taipei, Taiwan, ³Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ⁴Radiology, Cathay General Hospital, Taipei, Taiwan, ⁵Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan, ⁶Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan

Internal carotid artery stenosis (ICAS) has been identified as a risk factor of ischemic stroke, with altered flow velocity and narrowed lumen commonly assessed by ultrasonography and angiography. However, hemodynamic change/compensation in microvasculature cannot be ruled out before symptoms. In this study, we investigated cerebral perfusion changes in asymptomatic ICAS by simultaneously assessing cerebral blood flow (CBF), arterial transit time (ATT), and flow territory, derived from arterial spin-labeling (ASL) MRI. Our data suggest that ATT and flow territory may be better predictors of high-grade unilateral ICA stenosis (≥70 %) than CBF in asymptomatic patients.

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