Predicting clinical outcome following stroke remains a challenge for magnetic resonance imaging (MRI). In this study, we acquired longitudinally (3 sessions) multiparametric MRI data sets including diffusion-weighted and perfusion-weighted images of 30 patients with chronic ischemic stroke. All of the diffusion and perfusion MRI parameters were analyzed by the classic whole-lesion approach and the parametric response map (PRM), a voxel-based post-processing approach at each time point. The results emphasized the superiority of the PRM over the whole-lesion approach for the prediction of long-term outcome based on early MRI data.
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