Abstract #4473

The Metabolic Secretome of Cachexia Inducing Pancreatic Ductal Adenocarcinoma

Santosh K Bharti¹, Paul T Winnard Jr.¹, Louis Dore-Savard², Yelena Mironchik¹, Marie-France Penet^1,3, and Zaver M Bhujwalla^1,3

¹JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Experimental Therapeutics and Metabolism Program, McGill University Health Center, Montreal, QC, Canada, ³Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Tumor interstitial fluid (TIF) contains the secretome of cancers that can impact most phenotypic aspects of cancer. One characteristic phenotype of pancreatic ductal carcinoma (PDAC) is its ability to induce profound weight loss or cachexia through a multifactorial syndrome that affects multiple organs. To understand the interaction between cancer cells and body organs, here, for the first time, we have characterized the metabolomic profile of TIF from cachexia and non-cachexia inducing pancreatic cancer xenografts and identified clear differences in the metabolic secretome between cachexia inducing and the non-cachexia inducing tumors.

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