Abstract #4383

Model-based and Non-model-based Perfusion-related Predictors of Response to Chemotherapy in Intrahepatic Cholangiocarcinoma

Kristen Zakian¹, Aditi Iyer¹, Aditya Apte¹, Taryn Boucher², William Jarnagin³, Nancy Kemeny⁴, and Richard Do²

¹Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ²Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ³Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ⁴Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, United States

Hepatic arterial infusion of floxuridine has shown benefit in intrahepatic cholangiocarcinoma. Due to the complexity and expense of this treatment, a pre-treatment or early biomarker of efficacy would be advantageous. We employed non-model-based (NMB) analysis to maximize information from breath-motion degraded DCE-MRI in 24 patients. Model-based and NMB parameters were compared to RECIST response. The kurtosis value of pre-treatment time-to-half-maximum correlated with response, as did 1 month changes in perfusion parameters (K^trans and signal at half maximum). NMB analysis resulted in fewer voxels being discarded due to motion and thus may be more representative of tumor physiology while not requiring modeling.

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