Quantitative perfusion analysis in rectal cancer with DCE-MRI is highly dependent on the choice of the arterial input function (AIF). In nineteen patients it was investigated whether the selection affects the quantification of plasma flow (PF) applying with three different perfusion models (fast deconvolution algorithm, two-compartment uptake model, two-compartment exchange model). Results show disagreements in PF between the two AIFs for all three models with significant differences for the two-compartment exchange and uptake model.
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