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Abstract #3500

On the use of Gadolinium-staining for high resolution ex vivo NODDI measurements at 11.7T

Sophie Bernadette Sébille1,2, Anne-Sophie Rolland2, Romain Valabregue1,2, Carine Karachi2,3, Marie-Laure Welter2,4, Stéphane Lehéricy1,2, Eric Bardinet1,2, and Mathieu David Santin1,2

1Center of NeuroImaging Research - CENIR, Paris, France, 2Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France, 3AP-HP, Hôpital de la Pitié-Salpêtrière, Department of Neurosurgery, Paris, France, 4AP-HP, Hôpital de la Pitié-Salpêtrière, Department of Neurology, Paris, France

The goal of this work was to compare diffusion and microstructure parameters estimation when the sample is soaked or not in gadolinium before imaging (Gd-staining). We found that Gd-staining is suitable for diffusion imaging experiment, leading to higher SNR and higher useful b-values. Meanwhile, care must be taken for several microstructure parameters estimation as T1 may vary during experiment.

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