A new diffusion imaging method, single-scan diffusion mapping through overlapping-echo detachment planar (DM-OLED) imaging sequence with corresponding separation algorithm, was proposed. The method can get reliable diffusion mapping by a single-scan in about 120ms.The diffusion mapping gained by DM-OLED has immunity to motion and higher time resolution compared with conventional multi-scan diffusion methods. Experimental results of mouse brains verified the accuracy and the motion-tolerance of DM-OLED. As a reliable fast diffusion measurement tool, DM-OLED can be boded well for further uses in clinical real-time measurements.
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