Diffusion Tensor Imaging (DTI) is a widely used neuroimaging technique, but it lacks specificity. Advanced diffusion models aim to yield greater biophysical information than DTI. This information is redundant if the parameters cannot be accurately reproduced across time-points. Multi-shell diffusion images were acquired on a single 3T scanner at two time-points for ten healthy adults. Mean parameter values from SMT-based microscopic diffusion anisotropy imaging and DTI were obtained in white matter, cortex and thalami. The advanced model performed similarly well to DTI in white matter, but was less consistent in the cortex and thalami, potentially due to its increased complexity.
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