Abstract #3470

Diffusion-weighted MRI of node tissue: correlation of mean diffusivities and cellularity.

Mariaulpa Sahalan¹, Aritrick Chatterjee¹, Nyoman Kurniawan², Gary Cowin², Laurence Gluch³, Carl Power⁴, Geoffrey Watson⁵, Kevin Tay⁶, Julie Fletcher⁷, David Taylor⁸, and Roger Bourne¹

¹Faculty of Health Sciences, The University of Sydney, NSW, Australia, ²Centre for Advanced Imaging, University of Queensland, Brisbane, Australia, ³The Strathfield Breast Centre, NSW, Australia, ⁴Biological Resources Imaging Laboratory, University of New South Wales, NSW, Australia, ⁵Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, NSW, Australia, ⁶Westmead Breast Cancer Institute, NSW, Australia, ⁷Concord Repatriation General Hospital, NSW, Australia, ⁸Vetnostics, NSW, Australia

Improvement of sensitivity and specificity in DWI-based assessment of nodal diseases is dependent on a better understanding of how nodal microstructures affect the water diffusivity in tissue. In this abstract we report the first diffusion microimaging investigation of formalin fixed node tissue with the aim of assessing any correlation between mean diffusivity and cellularity. Mean diffusivity was calculated in ROI corresponding to distinct node sub-structures. Nuclei were segmented semi-automatically to measure the cellularity metrics: nuclear count and nuclear area. The results showed there is no significant correlation between mean diffusivity with cellularity metrics in the nodal tissues.

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