Meeting Banner
Abstract #3428

Inter-ethnic variation and SCD1 polymorphism predict risk for intramyocellular lipid accumulation in early childhood

Navin Michael1, Varsha Gupta1, Suresh Anand Sadananthan1, Aparna Sampathkumar1, Li Chen1, Hong Pan1, Mya Thway Tint2, Kuan Jin Lee3, Lynette Pei-Chi Shek4, Yap Kok Peng Fabian5,6, Keith M Godfrey7, Melvin Khee-Shing Leow8,9, Yung Seng Lee1,4, Michael S Kramer2,10,11, Yap Seng Chong1,2, Christiani Jeyakumar Henry8, Marielle Valerie Fortier12, Peter D Gluckman1,13, Neerja Karnani1,14, and S. Sendhil Velan3

1Singapore Institute for Clinical Sciences, A*STAR, Singapore, 2Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 3Singapore BioImaging Consortium, A*STAR, Singapore, 4Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 5Department of Paediatric Endocrinology, KK Women’s and Children’s Hospital, Singapore, 6Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 7MRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, 8Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, A*STAR, Singapore, 9Department of Endocrinology, Tan Tock Seng Hospital, Singapore, 10Department of Paediatrics, Faculty of Medicine, McGill University, Montreal, Canada, 11Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Canada, 12Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore, 13Liggins Institute, University of Auckland, Auckland, New Zealand, 14Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

A large intramyocellular lipid (IMCL) pool is associated with early pathogenesis of insulin resistance and type 2 diabetes. Studies from mother-offspring cohorts indicate that, like obesity and metabolic traits, IMCL is also highly heritable. However, here have been not many studies on the effect of genetic variation on IMCL. Although a number of genome-wide association studies (GWAS) have established associations between several genetic loci and metabolic disorders, it is not yet known if these loci also contribute to IMCL levels, and help explain ethnic difference in IMCL levels. In this study, we examined the ethnic differences (Indian, Malay and Chinese) in IMCL in Singaporean children and the genetic risk variant(s) associated with these differences.

This abstract and the presentation materials are available to members only; a login is required.

Join Here

Abstract E-Poster Video