Abstract #3423

Feasibility of diffusion kurtosis imaging as a tool for differentiation between benign and malignant uterine lesions

Yoshihiko Fukukura¹, Yuichi Kumagae¹, Masanoari Nakajo¹, Kiyohisa Kamimura¹, Aya Umanodan¹, Takashi Iwanaga², Tomoyuki Okuaki³, and Takashi Yoshiura¹

¹Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, ²Radiological Technology, Kagoshima University Hospital, Kagoshima, Japan, ³Philips Electronics Japan, TN, Japan

This study focused on the feasibility of DKI for differentiating benign from malignant uterine lesions. The ADC and D of malignant tumor (MT) were significantly lower than those of endometrial hyperplasia (EH) (p=0.005 and 0.004), uterine fibroid (UF) (both, p<0.001), normal endometrium (NE) (both, p<0.001), and normal myometrium (NM) (both, p<0.001), which indicative of the increased cellularity within uterine malignant tumor that resulted in restricted water diffusion. K was significantly higher in MT than in EH (p=0.003), UF (p<0.001), NE (p<0.001), and NM (p<0.001), possibly representing complexity of tissue microstructure in MT compared to benign lesions. DKI enables differentiate benign from malignant uterine lesions.

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