Abstract #3422

Use of texture analysis of intravoxel incoherent motion (IVIM) in evaluating the expression of Ki67 of hepatitis B virus-related hepatocellular carcinoma (HCC)

Qungang Shan¹, Jingbiao Chen¹, Ronghua Yan¹, Yao Zhang¹, Hao Yang¹, Xin Li², Zhongping Zhang³, Yunhong Shu⁴, Churong Lin, Tianhui Zhang¹, Bingjun He¹, Zhuang Kang¹, Xi Long¹, and Jin Wang¹

¹Department of Radiology, the Third Affiliated Hospital, Sun Yat-sen University (SYSU), Guangzhou, People's Republic of China, ²GE Healthcare MR Research China, Guangzhou, People's Republic of China, ³MR Research China,GE Healthcare, Beijing, ⁴Mayo Clinic

HCC is the second cause of cancer-related deaths and most HCC patients are accompanied with hepatitis B virus-related cirrhosis in China. Ki67 is a protein reflecting the proliferative activity of HCC and could be used as a predictor of prognosis. We assessed the value of the texture parameters in evaluating the expression of Ki67of HBV-related HCCs by whole tumor analysis. Our results showed that Dclusterprominence showed best diagnostic performance among all texture parameters. ADC and IVIM derived texture parameters might be used as useful and noninvasive biomarkers for evaluating the expression of Ki67 of HBV-related HCCs.

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