A method is presented that extends the concept of calculated DWI for the generation of high tissue contrast from trace-weighted data. Using the whole range of b-values including the physically inaccessible negative b-values, image segmentation, visual hinting and ROI generation can be provided for assistance of the clinical readers. 24 patient data sets involving different pathologies were used to test the feasibility and clinical potentials of the new approach. It was found that the extrapolation to negative b-values helps to extract fluid regions, whereas internal structures of lesions and noise masking may be obtained with high b-values.
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