Double diffusion encoding (DDE) experiments with two weighting periods applied successively in the same acquisition are a promising tool to investigate microscopic tissue properties, e.g. the cell eccentricity and the related diffusion anisotropy on a microscopic scale. Recent experiments detected the signal pattern typical for microscopic diffusion anisotropy in human cortical gray matter in vivo but were hampered by an additional signal modulation that could be related to field inhomogeneities near the skull. In this study, cross-term-compensated DDE experiments are performed to investigate the effect of field inhomogeneities on the detection of the microscopic diffusion anisotropy.
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