Abstract #3311

Repeatability of regional lung ventilation quantification using 19F fluorinated gas washout magnetic resonance imaging in free breathing

Marcel Gutberlet^1,2, Andreas Voskrebenzev^1,2, Agilo Kern^1,2, Till Kaireit^1,2, Jens Hohlfeld^2,3, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute of Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany, ³Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

Since quantification of regional lung ventilation using ¹⁹F fluorinated gas washout imaging in free breathing is feasible even in obstructed lungs, it may improve diagnosis, monitoring and therapy of obstructive lung diseases like asthma and COPD. However, for application in clinical studies the knowledge of the accuracy of this technique is important. Repeatability of the ¹⁹F gas washout parameters washout time, number of breaths and fractional ventilation between to scans was assessed in eight healthy volunteers. Due to the excellent repeatability of the number of breaths and fractional ventilation, regional lung ventilation can be accurately quantified using ¹⁹F gas washout MRI in free breathing.

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