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Abstract #3310

Repeatability of global percent enhancement and regional defect quantification in oxygen-enhanced 3D radial ultrashort echo time MRI

Wei Zha1, Stanley J Kruger1, Kevin M Johnson1,2, Robert V Cadman1, Andrew D Hahn1, Scott K Nagle1,2,3, and Sean B Fain1,2,4

1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Pediatrics, University of Wisconsin-Madison, Madison, WI, United States, 4Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Oxygen-enhanced 3D radial UTE MRI (OE-MRI) shows promise as an alternative to hyperpolarized gas MRI for evaluation of ventilation abnormalities. Ten subjects (2 normal, 2 asthmatics and 6 cystic fibrosis) underwent OE-MRI for multiple scans (test/re-test) during visits separated ≤15 days apart. The intra-subject percent signal enhancement (PSE) maps from OE-MRI were compared for median whole-lung PSE, ventilation defect percent (VDP) and spatial agreement between defects. The results suggest good agreement on two global measures, Median PSE and VDP, with low-to-moderate spatial alignment on the inter-visit segmented defects. Improvement of spatial defect repeatability will be a goal of future work.

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