Abstract #3196

Accurate hepatic MRI proton density fat fraction assessment can be achieved with four regions-of-interest

Cheng William Hong¹, Tanya Wolfson², Ethan Z Sy¹, Alexandra Schlein¹, Soudabeh Fazeli Dehkordy¹, Adrija Mamidipalli¹, Scott B Reeder³, Rohit Loomba⁴, and Claude B Sirlin¹

¹Liver Imaging Group, Department of Radiology, University of California, San Diego, San Diego, CA, United States, ²Computational and Applied Statistics Laboratory, University of California, San Diego, San Diego, CA, United States, ³Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, and Emergency Medicine, University of Wisconsin, Madison, Madison, WI, United States, ⁴NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Diego, San Diego, CA, United States

A common approach to estimating a composite proton density fat fraction (PDFF) on MRI-PDFF maps is to draw a region-of-interest (ROI) in each of the nine Couinaud segments. This is laborious and technically challenging, however. In this secondary analysis of 398 patients, we demonstrate that 4-ROI sampling strategies that sample 2 ROIs in each hepatic lobe achieve close agreement with the 9-ROI composite. With further validation, a simple 4-ROI sampling strategy may become the new standard for measuring PDFF in clinical trials.

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