Abstract #3033

SQUID-based ultralow field nuclear magnetic resonance spectroscopy using the para-H2 based hyperpolarization technique SABRE

Kai Buckenmaier¹, Matthias Rudolph^1,2, Christoph Back², Joern Engelmann¹, Juri Rudin¹, Tomasz Misztal³, Ute Bommerich⁴, Klaus Scheffler¹, Dieter Koelle², Reinhold Kleiner², Hermann Mayer³, Johannes Bernarding⁴, and Markus Plaumann⁴

¹High-field Magnetic Resonance, MPI for Biological Cybernetics, Tuebingen, Germany, ²Physikalisches Institut and Center for Quantum Science (CQ) in LISA+, University of Tübingen, Germany, ³Institue of Inorganic Chemistry, University of Tübingen, Germany, ⁴Department for Biometrics and Medical Informatics, Otto-von-Guericke-University Magdeburg, Germany

SABRE is a technique to achieve continuous hyperpolarization for MR measurements by the interaction of para-hydrogen and a substrate via steady ligand exchange on a catalyst. Thus, MR-active nuclei can be hyperpolarized more than only once. At field strengths of mT Faraday coils, commonly used in conventional or high field MRI, become insensitive and SQUIDs performing superior. Since SQUIDs are broadband detectors, the static magnetic field B₀ can be changed easily or multiple nuclei can be measured simultaneously. Here, we successfully demonstrate the advantages of a SQUID based system by showing significant signal enhancement (¹H, ¹⁹F) by hyperpolarization of 3-fluoropyridine.

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