Abstract #3032

Hyperpolarization of 2-keto[1-13C]isocaproate for in vivo studies with photo-induced radicals

Steffen F. Frank¹, Hikari A. I. Yoshihara², Mor Mishkovsky¹, Arnaud Comment³, and Rolf Gruetter^1,4,5,6

¹Laboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Institute of Physics of Biological Systems, Swiss Federal Institute of Technology, Lausanne, Switzerland, ³General Electric Healthcare, Chalfont Saint Giles, United Kingdom, ⁴Department of Radiology, University of Lausanne, Lausanne, Switzerland, ⁵Department of Radiology, University of Geneva, Geneva, ⁶Centre for Biomedical Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Hyperpolarized 2-keto[1-¹³C]isocaproate (KIC) provides a means to probe brain nitrogen homeostasis and to assess molecular signatures of tumors. The dynamic nuclear polarization process requires a free-radical polarizing agent, and samples are typically doped with persistent radicals. An alternative is to use photo-induced radicals of α-keto acids that recombine upon dissolution. [1-¹³C]KIC hyperpolarized with photo-induced radicals could be used to measure the alterations in amino acid metabolism that are linked to neurodegenerative diseases and cancer, and the aim of the present study is to identify the main features that influence the polarization dynamics.

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