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Abstract #2969

Assessment of Response to Radiation Therapy Using High-Resolution Proton MRSI in Soft Tissue Sarcoma Patients

Chao Ma1, Yen-Lin Chen2, Kyung-Wook Jee2, Ruth Lim1,2, Ivan A. Chebib3, Muge Oner Tamam1, Shuang Hu1,4, and Georges El Fakhri1

1Gordon Center for Medical Imaging, Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 3Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 4Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, People's Republic of China

As the recent rapid development of radiation therapy techniques glowingly facilitate an individualized adaptive radiation therapy (RT), the roles of imaging as a tool to assess the early treatment response to RT or to tailor the treatment volume are becoming important. Conventional structural MR images have limited specificities in delineating and differentiating between residual/recurrent tumor and treatment effects (e.g., edema, inflammation, and radiation necrosis). This work presents a pilot study to assess response to RT in soft tissue sarcoma (STS) patients using a recently proposed rapid high-resolution MRSI method: SPectroscopic Imaging by exploiting spatiospectral CorrElation (SPICE).

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