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Abstract #2952

Dynamic Oxygen-17 MR Imaging with Golden-Ratio-Based Radial Sampling and k-Space-Weighted Image Reconstruction

Yuchi Liu1,2, Yifan Zhang1,2, Chunying Wu2, Junqing Zhu2, Charlie Yi Wang1,2, Nicholas Tomko3, Mikhail Linetsky3, Robert Salomon3, Yanming Wang2,4, and Xin Yu1,2,4,5

1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States, 3Department of Chemistry, Case Western Reserve University, Cleveland, OH, United States, 4Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, 5Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

This study aimed at developing a 3D dynamic oxygen-17 (17O) MR imaging method to delineate the kinetics of 17O-water uptake and washout in mouse brain with glioblastoma at high temporal and spatial resolution. A 3D imaging method using a stack-of-stars golden-ratio-based radial sampling scheme was combined with k-space weighted image reconstruction to improve the temporal resolution with preserved spatial resolution. The proposed method achieved a temporal resolution of 7.56 s with a voxel size of 5.625 μL in mouse brain at 9.4T. It can also be used to image cerebral oxygen consumption rate in 17O inhalation studies.

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